Despite being a common disorder in some regions such as Europe, we cannot forget that Thalassaemia is a rare disease. But nowadays, thanks to blood transfusions and chelation therapy, surviving and life quality of thalassaemic patients have notably improved. The Guide «Living well with Thalassaemia» aims to provide a supporting tool to families and thalassaemic patients, in order to improve knowledge in the illness itself and in therapeutic solutions available to patients.