{"id":4681,"date":"2026-02-16T15:00:00","date_gmt":"2026-02-16T15:00:00","guid":{"rendered":"https:\/\/benzifoundation.org\/car-t-per-le-malattie-autoimmuni-risultati-significativi-nei-pazienti-pediatrici\/"},"modified":"2026-02-16T15:00:00","modified_gmt":"2026-02-16T15:00:00","slug":"car-t-per-le-malattie-autoimmuni-risultati-significativi-nei-pazienti-pediatrici","status":"publish","type":"post","link":"https:\/\/benzifoundation.org\/it\/car-t-per-le-malattie-autoimmuni-risultati-significativi-nei-pazienti-pediatrici\/","title":{"rendered":"CAR-T per le malattie autoimmuni: risultati significativi nei pazienti pediatrici"},"content":{"rendered":"

Uno studio straordinario, frutto della ricerca condotta presso l\u2019Ospedale Pediatrico Bambino Ges\u00f9 in collaborazione con l\u2019Universit\u00e0 di Erlangen, \u00e8 stato recentemente pubblicato sulla rivista scientifica Nature Medicin<\/em>e.<\/p>\n

Otto pazienti pediatrici affetti da malattie autoimmuni resistenti ai trattamenti sono riusciti a sospendere completamente le terapie immunosoppressive dopo aver ricevuto un trattamento con cellule CAR-T<\/strong>, una forma di terapia avanzata.
I bambini erano affetti da forme particolarmente aggressive di malattie autoimmuni a esordio pediatrico: quattro soffrivano di Lupus eritematoso sistemico, tre di Dermatomiosite (una rara patologia infiammatoria autoimmune) e uno di Sclerosi sistemica giovanile (una rara malattia autoimmune cronica). Tutti presentavano storie cliniche complesse, con risposte solo parziali o temporanee a numerose terapie immunosoppressive precedenti.<\/p>\n

Dopo il trattamento con cellule CAR-T, sette pazienti sono entrati in remissione clinica. L\u2019ottavo paziente, affetto da sclerosi sistemica, sta comunque mostrando una riduzione continua e significativa della gravit\u00e0 della malattia, senza segni di progressione.<\/p>\n

La terapia utilizza cellule CAR-T che colpiscono l\u2019antigene CD19 <\/strong>espresso dai linfociti B del sistema immunitario. Nelle malattie autoimmuni mediate dai linfociti B, queste cellule svolgono un ruolo centrale: la terapia le elimina in modo mirato, riducendo l\u2019infiammazione e ristabilendo l\u2019equilibrio del sistema immunitario<\/strong>. Questo approccio aumenta la probabilit\u00e0 di ottenere una remissione a lungo termine senza la necessit\u00e0 di terapie croniche<\/strong>.
I dati di follow-up, superiori ai 24 mesi, dimostrano che i benefici clinici si mantengono nel tempo.<\/p>\n

Questo studio rappresenta un risultato di grande rilevanza per le malattie autoimmuni pediatriche e rare, mostrando come le terapie avanzate<\/strong>, sviluppatesi rapidamente nell\u2019ultimo decennio, possano offrire nuove prospettive di trattamento e potenzialmente di cura.<\/p>\n

Per saperne di pi\u00f9: Su Nature Medicine lo studio che dimostra l’efficacia delle cellule CAR-T nelle malattie autoimmuni dell’et\u00e0 pediatrica – Ospedale Pediatrico Bambino Ges\u00f9<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Uno studio straordinario, frutto della ricerca condotta presso l\u2019Ospedale Pediatrico Bambino Ges\u00f9 in collaborazione con l\u2019Universit\u00e0 di Erlangen, \u00e8 stato recentemente pubblicato sulla rivista scientifica Nature Medicine. Otto pazienti pediatrici affetti da malattie autoimmuni resistenti ai trattamenti sono riusciti a sospendere completamente le terapie immunosoppressive dopo aver ricevuto un trattamento con cellule CAR-T, una forma […]<\/p>\n","protected":false},"author":2,"featured_media":4680,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[205],"tags":[229],"class_list":["post-4681","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-paediatric-research"],"yoast_head":"\nCAR-T per le malattie autoimmuni: risultati significativi nei pazienti pediatrici - Fondazione Gianni Benzi - ETS<\/title>\n<meta name=\"description\" content=\"Studio su Nature Medicine: terapia CAR-T efficace nelle malattie autoimmuni pediatriche con remissione clinica e stop agli immunosoppressori.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/benzifoundation.org\/it\/car-t-per-le-malattie-autoimmuni-risultati-significativi-nei-pazienti-pediatrici\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"CAR-T per le malattie autoimmuni: risultati significativi nei pazienti pediatrici - 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